HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → Methyl 3-(6-methoxypyridin-5-yl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Methyl beta-(2-methoxypyridin-5-yl)acrylate | HCID 53929170 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | Methyl 3-(6-methoxypyridin-5-yl)propionate | HCID 19082060 | 90% |
Reaction Steps
A suspension of methyl β-(6-methoxypyridin-3-yl)acrylate (3 g, 15.5 mmol) and 1 g of 5% Pd/C in 100 ml of ethyl acetate was hydrogenated under hydrogen (50 psi). After hydrogen uptake had ceased the mixture was filtered through solka floc, the filtrate was concentrated in vacuo to afford 2.7 g (90%) of methyl 3-(6-methoxypyridin-5-yl)propionate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763461 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-c35f6398837e4ffeb5c670e9f6bf781e |
| Source note | uspto-grants-1998_06 |