Trifluoroacetic acid → HCID 9882676, compound

Participants

Reaction Steps

1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-(tert-butoxycarbonyl)-piperidin-4-yl]propan-1-one (1.5 g, 3.8 mmol) was dissolved in methylene chloride (20 mL) and trifluoroacetic acid (5 mL) was added to the solution. After 30 minutes the solution was washed with aqueous ammonium hydroxide, and dried over sodium sulfate. Evaporation of the solvents gave 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(piperidin-4-yl)-propan-1-one (1.1 g, 3.8 mmol), m.p. 138°-140° C.

Provenance & Evidence