HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 963343Generated: October 26, 2026
Water → 1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one
https://huagongshe.com/reaction/963343
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one | HCID 19081861 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one | HCID 19081933 | 96.5% |
Reaction Steps
1-(4-Acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one (0.72 g, 2.26 mmol), sodium iodide (0.15 g, 0.1 mmol), and piperidine (1.72 g, 20 mmol) were combined in DMF (8.0 mL) and the mixture was heated to 80° C. for 4.5 hours. Water was then added to form a precipitate. Filtration gave 1-(4-acetylamino-5-chloro-2-methoxyphenyl)-5-(piperidin-1-yl)pentan-1-one (0.8 g, 2.18 mmol), m.p. 74°-75° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05763458 |
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| Source dataset | uspto-grants-1998_06 |
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| ORD ID | ord-961cf621db1c4e61b496032ab17b2b88 |
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| Source note | uspto-grants-1998_06 |
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