HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 1-[4-Amino-5-chloro-2-(3,5-dimethoxybenzyloxy)-phenyl]-5-(4-hydroxypiperidin-1-yl)pentan-1-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Piperidin-4-ol | HCID 79341 | — |
| Reactant | HCID 19081830 | HCID 19081830 | — |
| Product | 1-[4-Amino-5-chloro-2-(3,5-dimethoxybenzyloxy)-phenyl]-5-(4-hydroxypiperidin-1-yl)pentan-1-one hydrochloride | HCID 19081928 | — |
Reaction Steps
Proceeding as in Example 4, Step (c), but replacing 1-(4-acetylamino-5-chloro-2-methoxyphenyl)-5-chloropentan-1-one with 1-[4-acetylamino-5-chloro-2-(3,5-dimethoxybenzyloxy)phenyl]-5-chloropentan-1-one and piperidine with 4-hydroxypiperidine, gave 1-[4-amino-5-chloro-2-(3,5-dimethoxybenzyloxy)-phenyl]-5-(4-hydroxypiperidin-1-yl)pentan-1-one hydrochloride, m.p. 220-222° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763458 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-281c9012c5ba4059b11fc2668125daf1 |
| Source note | uspto-grants-1998_06 |