Ammonium Hydroxide → HCID 54142805, compound

Participants

Reaction Steps

1-(4-Amino-5-chloro-2-methoxyphenyl)-3-hydroxy-3-(pyridin-4-yl)-propan-1-one (8.6 g, 28 mmol), prepared as in Example 6, Step (a), was dissolved in concentrated sulfuric acid (40 mL) and the solution was stirred at room temperature for 15 minutes. The solution was poured onto ice, basified with ammonium hydroxide, and then filtered to collect a yellow solid. Drying gave 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(pyridin-4-yl)-2-propen-1-one (7.6 g, 26 mmol), 209°-211° C.

Provenance & Evidence