Iodoethane → 1-[4-Amino-5-chloro-2-ethoxyphenyl]-5-(piperidin-1-yl)-pentan-1-one hydrochloride

Participants

Reaction Steps

Proceeding as in Example 12, Step (a), but replacing 1-(4-amino-5-chloro-2-methoxyphenyl)-3-{1-[2-(methylsulfonyl)aminoeth yl]piperidin-4-yl}propan-1-one with 1-[4-amino-5-chloro-2-methoxyphenyl]-5-(piperidin-1-yl)pentan-1-one, and then as in Example 12, Step (b), but replacing 3,5-dimethoxybenzyl chloride with iodoethane, gave 1-[4-amino-5-chloro-2-ethoxyphenyl]-5-(piperidin-1-yl)-pentan-1-one hydrochloride, m.p. 230°-231° C.

Provenance & Evidence