反应详情

Proceeding as in Example 12, Step (a), but replacing 1-(4-amino-5-chloro-2-methoxyphenyl)-3-{1-[2-(methylsulfonyl)aminoeth yl]piperidin-4-yl}propan-1-one with 1-[4-amino-5-chloro-2-methoxyphen yl]-5-(piperidin-1-yl)pentan-1-one, and then as in Example 12, Step (b), but replacing 3,5-dimethoxybenzyl chloride with 1-bromopropane, gave 1-[4-amino-5-chloro-2-(prop-1-yloxy)phenyl]-5-(piperidin-1-yl)pentan-1-one hydrochloride, m.p. 232°-233° C.