Sodium Hydroxide → HCID 53720939, compound

Participants

Reaction Steps

1.86 g of 3-aminophenyl-boric acid hemisulphate are suspended are suspended in 20 ml of water and treated with 5 ml of a 2N sodium hydroxide solution. The clear, yellowish solution is treated dropwise while cooling with ice with a solution of monoethyl malonyl chloride in 7 ml of tetrahydrofuran. The mixture is stirred at room temperature for a further 15 min. and the precipitate is filtered off under suction. It is recrystallized in 50 ml of water. 1.12 g (45%) of 3-(2-ethoxycarbonylacetylamino)-phenylboric acid are isolated. M.p. 247°.

Provenance & Evidence