Tetrabutylammonium Fluoride Trihydrate → HCID 19081616, compound

Participants

Reaction Steps

267 mg of 5-(4'-t-butyl-dimethylsilyloxy-5,6-dimethoxybiphenyl-3-ylmethyl)-pyrimidine-2,4-diamine (Example 2f)) are dissolved in 6 ml of tetrahydrofuran and treated with 361 mg of tetrabutylammonium fluoride trihydrate. The mixture is stirred at room temperature for 1hr. and subsequently concentrated. The residue is chromatographed on MCl-Gel CHP20P (Mitsubishi Corporation) with water/acetonitrile 4:1. 73 mg (36%) of 5-(4'-hydroxy-5,6-dimethoxy-biphenyl-3-ylmethyl)-pyrimidine-2,4-diamine are isolated as a colourless solid. M.p. 233°.

Provenance & Evidence