Potassium Hydroxide → HCID 19081610, compound

Participants

Reaction Steps

640 mg of 5-(3'-(2-methoxycarbonylethyl-amino)-5,6-dimethoxy-biphenyl-3-ylmethyl)-pyrimidine-2,4-diamine (Example 4n)) are treated with 8 ml of a 1M solution of potassium hydroxide in methanol and stirred at room temperature for 10 hrs. Insoluble material is filtered off from the mixture and the filtrate is concentrated. The residue is chromatographed on MCl-Gel CHP20P (Mitsubishi Corporation) with water/acetonitrile 3:1. 180 mg (26%) of 5-(3'-(2-carboxyethyl-amino)-5,6-dimethoxy-biphenyl-3-ylmethyl)-pyrimidine-2,4-diamine are isolated as a white yellowish solid. M.p. 136°-140° (decomposition).

Provenance & Evidence