Hydrochloric Acid → HCID 69995363, compound

Participants

Reaction Steps

82 mg of ethyl 7-[5-(2,4-diamino-pyrimidin-5-ylmethyl)-2,3-dimethoxy-phenyl]-1-ethyl-1,4-dihydro-4-oxo-quinoline-3-carboxylate (Example 2t)) are held at reflux in 1 ml of ethanol and 1 ml of 2N aqueous sodium hydroxide solution for one hr. The reaction mixture is cooled to room temperature and acidified with 25% aqueous hydrochloric acid. The precipitated substance is filtered off under suction, washed with water, ethanol and ether and dried. 49 mg (59%) of 7-[5-(2,4-diamino-pyrimidin-5-ylmethyl)-2,3-dimethoxy-phenyl]-1-ethyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid hydrochloride are obtained as a colourless solid. M.p.>230° C. Mass spectrum (ISP): peaks: inter alia at 476 (M++H, 100%).

Provenance & Evidence