Ethyl acetate hexane → HCID 19081769, compound

Participants

Reaction Steps

500 mg of ethyl 2-(4-bromo-2-chloro-benzoyl)-3-[(tetrahydro-furan-2-ylmethyl)-amino]- acrylate and 148 mg of potassium t-butylate are held at 60° in 20 ml of DMSO for 30 mins. After chromatography on silica gel with ethyl acetate/hexane 1:1 343 mg of ethyl 7-bromo-4-oxo-1-(tetrahydro-furan-2-ylmethyl)-1,4-dihydro-quinoline-3-carboxylate are isolated as a yellowish oil. Yield: 75%. Mass spectrum: peaks inter alia at m/e: 380 (M++H, 100%).

Provenance & Evidence