Hydrochloric Acid → HCID 54127738, compound

Participants

Reaction Steps

13ay) A mixture of 1.53 g of 3-iodoaniline, 2.02 g of triethylamine and 0.1 g of 4-dimethylaminopyridine in 25 ml of THF is treated dropwise with 1.83 g of cyclopropanecarbonyl chloride and subsequently held at reflux for 4 hrs. The mixture is poured into 50 ml of ice-water, made weakly acid (pH about 4) with dil. HCl and extracted three times with ethyl acetate. Chromatography on silica gel with petroleum ether/ethyl acetate 4:1 gives 1.73 g (69%) of crude cyclopropanecarboxylic acid cyclopropanecarbonyl-(3-iodo-phenyl)-amide as a colourless oil with solidifies after a few days. Yield: 69%.

Provenance & Evidence