HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → HCID 47451380, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 3-Iodoaniline | HCID 12271 | — |
| Reactant | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 47451380 | HCID 47451380 | 60% |
Reaction Steps
1.15 g of 3-iodoaniline and 097 g of N-BOC-glycine are dissolved in 25 ml of methylene chloride and treated portionwise at 0° with 1.14 g of dicyclohexylcarbodiimide. The separated urea is filtered off and the filtrate is concentrated. Recrystallization from toluene yields tert.butyl [(3-iodo-phenyl-carbamoyl)-methyl]-carbamate as colourless crystals. Yield: 60%. M.p.=126°-128°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763450 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-a721d98f5e334642b0fe42ca3fa85208 |
| Source note | uspto-grants-1998_06 |