N-(4-bromophenyl)-1,1,1-trifluoromethanesulfonamide → HCID 69993988, compound

Participants

Reaction Steps

A solution of 1.52 g (5 mmol) of N-(4-bromophenyl)-C,C,C-trifluoro-methanesulphonamide (Example 13bv)) in 25 ml of ethyl orthoformate was heated to reflux for 6 hours. Subsequently, the readily volatile constituents were distilled off on a water-jet vacuum and the residue was chromatographed over a flash column with hexane/ethyl acetate 95:5. There were obtained 1.55 g (93%) of N-(4-bromophenyl)-N-ethyl-C,C,C- trifluoro-methanesulphonamide as a pale yellow oil. MS (EI): 331 and 333 (M+, 44%), 198 and 200 ([M-SO2 CF3 ]+, 80%), 118 ([M-(SO2CF3 +HBr)]+, 100%).

Provenance & Evidence