Methanesulfonic Acid → HCID 86752728, compound

Participants

Reaction Steps

A suspension of 0.2 g of 1-ethyl-7-[5-(2,4-diamino-pyrimidin-5-ylmethyl)-2,3-dimethoxy-phenylethynyl]-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (3-dimethylamino-propyl)-amide (Example 12z)) in 50 ml-of water is treated with a 0.1N aqueous methanesulphonic acid solution, with a slightly turbid solution being obtained. This solution is filtered and the filtrate is lyophilized. 1-ethyl-7-[5-(2,4-diamino-pyrimidin-5-yl-methyl)-2,3-dimethoxy-phenylethynyl]-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (3-dimethylamino-propyl)-amide dimethanesulphonate are obtained as a yellowish amorphous solid. Mass spectrum (FAB): 584 (M++H).

Provenance & Evidence