Hydrochloric Acid → HCID 19081731, compound

Participants

Reaction Steps

146 mg of 5-[3-(3,5-bis-methoxymethoxy-naphthalen-2-ylethynyl)-4,5-dimethoxybenzyl]-pyrimidin-2,4-diamine (Example 12ap)) in 2.5 ml of THF, 2.5 ml of water and 2.5 ml of 6N hydrochloric acid are held at 50° for 7.5 hrs. The mixture is concentrated and the residue is chromatographed on silica gel with methylene chloride/methanol 9:1. 59 mg of 6-[5-(2,4-diamino-pyrimidin-5-ylmethyl)-2,3-dimethoxy-phenylethynyl]-naphthalene-1,7-diol are isolated as a yellowish solid. Yield: 48%. Mass spectrum: peaks inter alia at 443 (M++H, 100%).

Provenance & Evidence