Sodium Hydroxide → HCID 19081598, compound

Participants

Reaction Steps

16bc) 150 mg of diethyl [4-[5-(2,4-diamino-pyrimidin-5-ylmethyl)-2,3-dimethoxy-phenylethynyl]-phenyl]-phosphonate (Example 12bo)) are dissolved in 5 ml of ethanol and treated with 5 ml of a 2N sodium hydroxide solution. The solution is held under reflux for 2 hrs., then cooled and chromatographed on MCl gel with water/acetonitrile. 43 mg of [4-[5-(2,4-diamino-pyrimidin-5-ylmethyl)-2,3-dimethoxy-phenylethynyl]-phenyl]-phosphonic acid disodium salt are isolated. Yield: 29%. Mass spectrum: peaks inter alia at m/e: 463 (M++Na, 30%), 441 (M++H, 100%), 412 (22%).

Provenance & Evidence