Hydrazine hydrate (1:1) → HCID 19081234, compound

Participants

Reaction Steps

To a solution of (3RS)-1-(benzothiophen-3-yl)methyl-2,3-dihydro-5-(2-fluorophenyl)-3-phtalimido-1H-1,4-benzodiazepin-2-one (0.980 g) in tetrahydrofuran (10 ml) was added dropwise hydrazine monohydrate (0.109 g) under stirring at ambient temperature. The mixture was stirred for 1 hour at the same temperature and refluxed under stirring for 2 hours. The reaction mixture was allowed to stand to ambient temperature. The resultant precipitates were filtered off and washed with tetrahydrofuran. The filtrate and washing were combined and concentrated in vacuo to afford a crude product. The crude product was purified by column chromatography on silica gel with an eluent of chloroform and methanol to afford (3RS)-3-amino-1-(benzothiophen-3-yl)methyl-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one.

Provenance & Evidence