Sodium Iodide → HCID 135829358, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (3RS)-3-acetoxy-5-cyclohexyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one (2.00 g) in N,N-dimethylformamide (15 ml) was added potassium phthalimide (1.85 g) under stirring and heated at 60° C. To the mixture was added sodium iodide (12.64 g) and stirred for 3 hours at 100° C. The hot resultant mixture was poured into ice-water to give a crude product. The precipitated crude product was collected by filtration. Dryness under the reduced pressure at 40° C. gave (3RS)-5-cyclohexyl-2,3-dihydro-3-phthalimido-1H-1,4-benzodiazepin-2-one (1.80 g) as an yellow powder, which was used in a following reaction step without further purification.

Provenance & Evidence