Hydrochloric Acid → HCID 19081311, compound

Participants

Reaction Steps

A solution of (3RS)-3-tert-butoxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1-(3-methoxycarbonylpyridin-2-yl) methyl-1H-1,4-benzodiazepin-2-one (0.80 g) in chloroform (10 ml) was treated with hydrogen chloride at room temperature and the mixture was stirred for 1 hour under the same condition. The mixture was concentrated in vacuo and the residue was taken up with chloroform. The organic layer was washed with a saturated sodium carbonate aqueous solution, dried over sodium sulfate, filtered and concentrated in vacuo to give (3RS)-3-amino-2,3-dihydro-5-(2-fluorophenyl)-1-(3-methoxycarbonylpyridin-2-yl)methyl-1H-1,4-benzodiazepin-2-one (0.64 g) as a colorless form.

Provenance & Evidence