Hydrochloric Acid → HCID 19081186, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-hydroxyaniline (2.0 g) and pyridine (3.3 ml) in tetrahydrofuran was stirred at 0° C. and then p-nitrophenyl chloroformate (3.88 g) was added, stirred at the same temperature for 5 hours. Ethyl acetate and 1N HCl were added to the reaction mixture, and the organic layer was separated, washed with water, dried over magnesium sulfate, and evaporated in vacuo. The yellow powder was washed with ethyl acetate to afford 4-nitro-phenyl N-(3-hydroxyphenyl)carbamate (554 mg).

Provenance & Evidence