Benzoyl Peroxide → Methyl 5-(bromomethyl)thiophene-2-carboxylate

Participants

Reaction Steps

To a mixture of 2-dimethoxymethyl-5-methylthiophene (3.44 g, 20 mmol) and N-bromosuccinimide (4.63 g, 26 mmol) in carbon tetrachloride (50 ml) was added a catalytic amount of benzoylperoxide. The mixture was refluxed for 1 hour. Undissolved materials were filtered off. The filtrate and the washings were combined and evaporated in vacuo to give 2-methoxycarbonyl-5-bromomethyl-thiophene as a yellow oil (4.65 g}, which was used in a following reaction without further purification.

Provenance & Evidence