m-Tolyl isocyanate → HCID 19081346, compound

Participants

Reaction Steps

To a solution of (3RS)-3-amino-2,3-dihydro-5-(2-fluorophenyl)-1-(pyridin-3-yl)methyl-1H-1,4-benzodiazepin-2-one (0.48 g) in dry methylene chloride (30 ml) was added dropwise a solution of 3-methylphenyl isocyanate (0.195 g) in dry methylene chloride (5 ml) under nitrogen atmosphere at cooling in an ice-bath. The mixture was stirred under the same temperature for 1 hour and at ambient temperature overnight. The resultant precipitates were collected by filtration and washed with isopropyl ether to afford N-[(3RS)-2,3-dihydro-5-(2-fluorophenyl)-2-oxo-1-(pyridin-3-yl)methyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea.

Provenance & Evidence