Hydrochloric Acid → HCID 61135588, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-[(3RS)-1-(3-azabicyclo[3.2.2]non-3-yl)carbonylmethyl-2,3-dihydro-5-(2-fluorophenyl)-2-oxo-1H-1,4-benzodiazepin-3-yl]-N'-(3-cyanophenyl)urea, hydroxyamie hydrochloride and triethylamine in dimethylsulfoxide was stirred at 70° C. overnight. Ethyl acetate and water weretadded to the reaction mixture and the organic layer was separated, washed with water and brion, dried over magnesium sulfate, and evaporated to dryness. The crude powder was purified by column chromatography on silica gel to afford N-[(3RS)-1-(3-azabicyclol[3.2.2]non-3-yl)carbonylmethyl-2,3-dihydro-5-(2-fluorophenyl)-2-oxo-1H-1,4-benzodiazepin-3-yl]-N'-{3-[1-amino-1-hydroxyiminomethyl]-phenyl}urea.

Provenance & Evidence