Hydrochloric Acid → HCID 18660717, compound

Participants

Reaction Steps

The compound (2S,3S,5S)-5-amino-2-[N-(N-(2-pyridinyl-methoxy)valinyl)amino]-1,6-diphenyl-3-hydroxy hexane hydrochloride salt (LL-74A) was prepared from LL-74. The compound (2S,3S,5S)-5-[N-(tert-butyloxycarbonyl)amino]-2-[N-(N-(2-pyridinylmethoxy)valinyl)amino]-1,6-diphenyl-3-hydroxy hexane (LL-74, 108 mg, 0.183 mmol) was dissolved in 4.0M solution of HCl in dioxane (20 ml), and stirred at room temperature for 30 min. after which solvents were evaporated. The evaporation was repeated 3 times with ethyl ether (10 ml) and finally dried under vacuum. This compound (LL-74A) was used in next step without further purification. TLC [Rf =0.35 (chloroform:methanol, 8:2)]; HPLC (rt=12.6 min.); MS m/z 505 (M+H)+.

Provenance & Evidence