Trifluoroacetic acid → HCID 131720704, compound

Participants

Reaction Steps

Compound (2S,3S,5S)-5-amino-2-[N-((9-fluorenylmethoxy)carbonyl)amino]-1,6-diphenyl-3-hydroxy hexane TFA salt (LL-96) was prepared. Compound (2S,3S,5S)-5-[N-(tert-butyloxy carbonyl)amino]-2-[N-((9-fluorenylmethoxy)carbonyl)amino]-1,6-diphenyl-3-hydroxy hexane (LL-87, 787 mg, 1.3 mmol) was dissolved in trifluoroacetic acid (10 mL), and stirred at room temperature for 10 min. after which solvents were evaporated. The evaporation was repeated 3 times with ethyl ether (10 mL) and finally dried under vacuum. This compound (LL-96) was used in next step with out further purification.

Provenance & Evidence