Methanol → HCID 23675694, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 2-trifluoromethyl-2,5,5,6,6,7,7,8,8,8-decafluoro-octanoate (14.8 g, 0.035 mol), sodium hydroxide (1.64 g, 0.041 mol), water (25 mL) and methanol (25 mL) was stirred at ambient temperature for 2 hr and at 60° C. for 2 hr. After cooling, ethyl acetate was added to extract the product. The organic layer was separated, washed with brine, and dried over magnesium sulfate, and then the solvent was removed in vacuo. After drying overnight under high vacuum, the sodium 2-trifluoromethyl-2,5,5,6,6,7,7,8,8,8-decafluorooctanoate salt product, formula above, was obtained as a white to light brown low melting point solid in almost quantitative yield.

Provenance & Evidence