Ammonium Hydroxide → 2-Bromo-5-methoxybenzamide

HRID 963621노트

반응식

HRID 963621 반응식
[OH-].[NH4+:2].[Br:3][C:4]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:5]=1[C:6](Cl)=[O:7]>C(Cl)Cl>[Br:3][C:4]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:5]=1[C:6]([NH2:2])=[O:7]

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 27816562-Bromo-5-methoxybenzoyl chloride

생성물 1

HCID 27287052-Bromo-5-methoxybenzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A 30% ammonium hydroxide solution (56 mL) is added dropwise to a solution of 2-bromo-5-methoxybenzoyl chloride in methylene chloride at 0° C. After the addition is complete, the reaction mixture is filtered to obtain a solid which is air-dried and recrystallized from a methanol/water solution to give the title product as a white solid, mp 158°-159° C.

후처리

  1. additionAfter the addition
  2. filtrationthe reaction mixture is filtered
  3. customto obtain a solid which
  4. customis air-dried
  5. customrecrystallized from a methanol/water solution

출처 및 근거

ORD 기록
ord-652f8aacd99c4ab880d3e19d6e1ce17a
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05763605

반응 노트

불러오는 중…