HCID 86752572, compound → HCID 86752571, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of dihydro-3-bromo-1-pyrindine-6,6-bisphosphonic acid, tetraethyl ester (10 mmol) [prepared as described in Example E (part I) hereinbefore] in THF (10 ml) cooled to -78° C. is added a solution of n-butyllithium (2.1 equivalent) in hexane over 30 minutes. The reaction is kept at -78° C. for an additional 30 minutes. To this solution is added 4-iodobutanol trimethylsilyl (TMS) ether (2.5 equivalent) and the reaction is allowed to warm to room temperature over 30 minutes. After standard aqueous work-up, dihydro-3-(4-butanol, TMS ether)-1-pyrindine-6,6-bisphosphonic acid, tetraethyl ester is isolated and used in the next reaction without purification.

Provenance & Evidence