HCID 86748470, compound → HCID 86748469, compound

HRID 963650Notes

Reaction equation

HRID 963650 reaction equation
[CH:1]1[NH:2][CH:3]=[CH:4][C:5]2[C:9]=1[C:8]([C:10]([O:12][CH3:13])=[O:11])=[CH:7][CH:6]=2.[H][H]>[Pd].CO>[CH2:1]1[C:9]2[C:5]([CH:6]=[CH:7][C:8]=2[C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH2:3][NH:2]1

Participants

5

Reactant 2

HCID 86748470HCID 86748470, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86748469HCID 86748469, compoundYield 53.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A hydrogenation bottle is charged with 2-pyrindine-7-carboxylic acid, methyl ester (0.8 g, 4.57 mmol), 5% Pd on carbon (2.0 g, wet) and methanol (125 ml). The slurry is hydrogenated (40 psi) until hydrogen uptake stops. The reaction mixture is filtered through celite and then evaporated to dryness to provide the product (430 mg) in 53% yield.

Workup

  1. filtrationThe reaction mixture is filtered through celite
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-ad6e5857c2824c84a81b9f3db5a232bb
Source dataset
uspto-grants-1998_06
Patent number
US05763611

Reaction notes

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