Isopropylamine → 2-[6-[3-Chloro-5-fluoro-4-(trifluoromethyl)phenoxy]benzotriazol-1-yl]propanoic acid;propan-2-amine

HRID 963659Notes

Reaction equation

HRID 963659 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].[Cl:5][C:6]1[CH:11]=[C:10]([O:12][C:13]2[CH:14]=[CH:15][C:16]3[N:20]=[N:19][N:18]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])[C:17]=3[CH:26]=2)[CH:9]=[C:8]([F:27])[C:7]=1[C:28]([F:31])([F:30])[F:29]>C(Cl)Cl.C1(C)C=CC=CC=1>[CH:1]([NH2:4])([CH3:3])[CH3:2].[Cl:5][C:6]1[CH:11]=[C:10]([O:12][C:13]2[CH:14]=[CH:15][C:16]3[N:20]=[N:19][N:18]([CH:21]([CH3:25])[C:22]([OH:24])=[O:23])[C:17]=3[CH:26]=2)[CH:9]=[C:8]([F:27])[C:7]=1[C:28]([F:31])([F:30])[F:29]

Participants

5

Reactant 2

HCID 6363IsopropylamineHCID 867479436-[(2-chloro-alpha,alpha,alpha,6-tetrafluoro-p-tolyl)oxy]-alpha-methyl-1H-benzotriazole-1-acetic acid

Product 1

HCID 867479452-[6-[3-Chloro-5-fluoro-4-(trifluoromethyl)phenoxy]benzotriazol-1-yl]propanoic acid;propan-2-amine

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Procedure

Isopropylamine (0.5 g, 0.0085 mole) is added to a solution of 6-[(2-chloro-α,α,α,6-tetrafluoro-p-tolyl) oxy]-α-methyl-1H-benzotriazole-1-acetic acid (2.0 g, 0.005 mole) in methylene chloride and the resultant solution is concentrated in vacuo to afford a gum which is dissolved in toluene. The toluene solution is concentrated to afford the title compound as a white solid, mp 103.5°-105.5°, identified by elemental and NMR analyses.

Workup

  1. concentrationthe resultant solution is concentrated in vacuo
  2. customto afford a gum which
  3. concentrationThe toluene solution is concentrated

Sources & evidence

ORD record
ord-3b5eeb1277d64a5faa13767a3fbbfe66
Source dataset
uspto-grants-1998_06
Patent number
US05763615

Reaction notes

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