Sodium ion → 7-(2-Fluoro-4-methylsulfonylphenyl)-4-[1-(5-fluoropyrimidin-2-yl)piperidin-4-yl]oxy-5,6-dihydropyrrolo[2,3-d]pyrimidine

HRID 96368Notes

Reaction equation

HRID 96368 reaction equation
[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[N:8]([c:11]1[c:12]([F:21])[cH:13][c:14]([S:17](=[O:18])(=[O:19])[CH3:20])[cH:15][cH:16]1)[CH2:9][CH2:10]2.[F:24][c:25]1[cH:26][n:27][c:28]([N:31]2[CH2:32][CH2:33][CH:34]([OH:37])[CH2:35][CH2:36]2)[n:29][cH:30]1.[H-:23].[Na+:22]>>[c:2]1([O:37][CH:34]2[CH2:33][CH2:32][N:31]([c:28]3[n:27][cH:26][c:25]([F:24])[cH:30][n:29]3)[CH2:36][CH2:35]2)[c:3]2[c:4]([n:5][cH:6][n:7]1)[N:8]([c:11]1[c:12]([F:21])[cH:13][c:14]([S:17](=[O:18])(=[O:19])[CH3:20])[cH:15][cH:16]1)[CH2:9][CH2:10]2

Participants

5

Reactant 4

HCID 923Sodium ionHCID 166653HydrideHCID 426368224-Chloro-7-(2-fluoro-4-(methylsulfonyl)phenyl)-6,7-dihydro-5H-pyrrolo[2,3-D]pyrimidineHCID 601378121-(5-Fluoropyrimidin-2-yl)piperidin-4-ol

Product 1

HCID 580170497-(2-Fluoro-4-methylsulfonylphenyl)-4-[1-(5-fluoropyrimidin-2-yl)piperidin-4-yl]oxy-5,6-dihydropyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record
ord-d2211fe97fbf4babbbfeee3ee9976ca6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…