HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 178467377, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Trityl candesartan cilexetil | HCID 11029254 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178467377 | HCID 178467377 | 95.4% |
Reaction Steps
Using 10.0 g of (+)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[2'-(N-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methylbenzimidazole-7-carboxylate, the reaction and after-treatment of Example 1 was repeated except that ethanol was used in lieu of methanol. The procedure provided 6.83 g of (±)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylbenzimidazole-7-carboxylate (yield 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763619 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-f86980f87b2c46768472240e31189769 |
| Source note | uspto-grants-1998_06 |