HCID 19083200, compound → HCID 54415848, compound

Participants

Reaction Steps

2-[1-(1-Cyclopropylcarbamoyl-2,2-dimethyl-propylcarbamoyl)-3-methyl-butyl]-pent-4-enoic acid-tert-butyl ester (2.05 g, 4.83 mmol) was dissolved in dichloromethane (7 ml) and TFA (7 ml). The mixture was allowed to stand at 0°-5° C. overnight then solvent was evaporated under reduced pressure, azeotroping with three times toluene to provide the title compound as a white solid which was recrystallised from ethyl acetate. Yield: 1.81 g (74%). 1H-NMR; δ (CD3OD), 8.19 (1H, br s), 7.95 (1H, d, J=9.2 Hz), 5.72 (1H, m), 4.98 (2H, m), 4.19 (1H, d, J=9.3 Hz), 2.76 (1H,m), 2.56 (2H, m) 2.23 (1H, m), 1.59 (1H, m), 1.37 (1H, m), 0.96 (9H, s), 0.87 (3H, d,J=6.5 Hz), 0.81 (3H, d, J=6.6 Hz), 0.68 (2H, m) and 0.43 (2H, m).

Provenance & Evidence