HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9637Generated: October 25, 2026
1-(4-(Trifluoromethyl)phenyl)ethan-1-one → 3-Dimethylamino-1-(4-trifluoromethyl-phenyl)-but-2-en-1-one
https://huagongshe.com/reaction/9637
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(4-(Trifluoromethyl)phenyl)ethan-1-one | HCID 69731 | — |
| Reactant | 1,1-Dimethoxyethyl(dimethyl)amine | HCID 87835 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-Dimethylamino-1-(4-trifluoromethyl-phenyl)-but-2-en-1-one | HCID 69234633 | — |
Reaction Steps
A mixture of 4′-(trifluoromethyl)acetophenone (9.8 g) and N-(1,1-dimethoxyethyl)-N,N-dimethylamine (8.2 g) was heated at 112° C. overnight, under nitrogen. The reaction mixture was cooled and concentrated giving an orange solid. Trituration with diethyl ether gave the title compound as a yellow solid
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07091237B2 |
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| Source dataset | uspto-grants-2006_08 |
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| ORD ID | ord-1ea84c7acf084517a9e9625c59ac88bf |
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| Source note | uspto-grants-2006_08 |
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