HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → 2-(4-Chloro-2-nitrophenyl)ethoxycarbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 2-(4-Chloro-2-nitrophenyl)ethanol | HCID 14491512 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(4-Chloro-2-nitrophenyl)ethoxycarbonyl chloride | HCID 19082706 | 95% |
Reaction Steps
Phosgene was introduced in a solution of 2-(4-chloro-2-nitrophenyl)ethanol (6.8 g, 34 mmol) in THF (50 ml, dist. over CaH2) at room temperature. After 2.5 h, the excess phosgene and the solvent were removed by distillation in a high vacuum. 2-(4-chloro-2-nitrophenyl)ethoxycarbonyl chloride (8.53 g, 95%) was obtained as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763599 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-8c51da2b51054dae98ecad22212d01ab |
| Source note | uspto-grants-1998_06 |