HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → 2-(5-Methoxy-2-nitrophenyl)ethyl carbonochloridate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 5-Methoxy-2-nitrobenzeneethanol | HCID 13843581 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(5-Methoxy-2-nitrophenyl)ethyl carbonochloridate | HCID 19082694 | 96% |
Reaction Steps
Phosgene was introduced in a solution of 2-(5-methoxy-2-nitrophenyl)ethanol (3.0 g, 15 mmol) in THF (40 ml, dist. over CaH2) at room temperature under stirring. After 2.5 h the excess phosgene and the solvent were removed by distillation in a high vacuum. 2-(5-methoxy-2-nitrophenyl)ethoxycarbonyl chloride (3.72 g, 96%) was obtained as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763599 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-eddf8bd218b5471aad1f61f9ba75db68 |
| Source note | uspto-grants-1998_06 |