Formaldehyde → HCID 19082696, compound

Participants

Reaction Steps

A solution of 2-nitrobenzyl chloride (4.3 g, 25 mmol) in DMSO (3.5 ml, synthesis quality, additionally dried for 2 d over molecular sieve 4 Å) was mixed with paraformaldehyde (750 mg, 25 mmol) and DBU (0.5 ml, 3.3 mmol) and stirred at room temperature for 20 min. The pH value of the reaction mixture was adjusted to about pH 3 by means of a few drops of conc. AcOH. The mixture was diluted with CH2Cl2 (120 ml), washed with H2O (80 ml) and post-extracted with CH2Cl2 (2×100 ml).

Provenance & Evidence