反应详情

温度

0 °C

37.2 g of 5-iodo vanillin (commercial) and 360 ml of dichloromethane were mixed together under nitrogen and the mixture was cooled to 0° C. 135 ml of a molar solution of boron tribromide in dichloromethane were added and the mixture stood for 16 hours at ambient temperature and was then concentrated, cooled to 0° C. and acidified. The crystallized product was separated out, washed with water, dried and crystallized from an isopropanol-water mixture (1-2 by volume) to obtain 23.4 g of the expected product.

1. concentrationwas then concentrated
2. temperaturecooled to 0° C.
3. customThe crystallized product was separated out
4. washwashed with water
5. customdried
6. customcrystallized from an isopropanol-water mixture (1-2 by volume)