HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 1-(4-Ethoxyphenyl)-1-(2-fluoro-2-(methoxycarbonyl)ethenyl)cyclopropane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 1-(4-Ethoxyphenyl)cyclopropane-1-carbaldehyde | HCID 13537252 | — |
| Reactant | Methyl 2,2-dichloro-2-fluoroacetate | HCID 13612258 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Ethoxyphenyl)-1-(2-fluoro-2-(methoxycarbonyl)ethenyl)cyclopropane | HCID 54288369 | 62.7% |
Reaction Steps
The method of Example 1 was repeated using zinc powder (4.1 g), copper (I) chloride (0.63 g), molecular sieve 4A (4.2 g), tetrahydrofuran (72 ml), 1-(4-ethoxyphenyl)-1-formylcyclopropane (4.7 g), acetic anhydride (2.6 ml) and methyl dichloro-fluoroacetate (3.3 g) to yield the title compound (3.4 g, 52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763700 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-6dfe3b85286e4a63a3fc004dc93e6424 |
| Source note | uspto-grants-1998_06 |