HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 1-(2-Fluoro-2-(methoxycarbonyl)ethenyl)-1-(2-fluoro-4-trifluoromethylphenyl) cyclopropane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Methyl 2,2-dichloro-2-fluoroacetate | HCID 13612258 | — |
| Reactant | 1-[2-Fluoro-4-(trifluoromethyl)phenyl]cyclopropane-1-carbaldehyde | HCID 19083335 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(2-Fluoro-2-(methoxycarbonyl)ethenyl)-1-(2-fluoro-4-trifluoromethylphenyl) cyclopropane | HCID 54160134 | 44% |
Reaction Steps
The method of Example 1 was repeated using zinc powder (1.3 g), copper (I) chloride (0.22 g), molecular sieve 4A (1.6 g), tetrahydrofuran (20 ml), 1-(2-fluoro-4-tri-fluoromethylphenyl)-1-formylcyclopropane (1.39 g), acetic anhydride (0.58 ml) and methyl dichlorofluoroacetate to yield the title compound (0.81 g, 44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763700 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-d3f6d3674a45445c9403249d4357c0f8 |
| Source note | uspto-grants-1998_06 |