HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 1-(4-Difluoromethoxyphenyl)-1-(2-fluoro-2(methoxycarbonyl)ethenyl)cyclopropane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Methyl 2,2-dichloro-2-fluoroacetate | HCID 13612258 | — |
| Reactant | 1-[4-(Difluoromethoxy)phenyl]cyclopropane-1-carbaldehyde | HCID 19083342 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Difluoromethoxyphenyl)-1-(2-fluoro-2(methoxycarbonyl)ethenyl)cyclopropane | HCID 53901416 | 28% |
Reaction Steps
The method of Example 1 was repeated using zinc powder (2.8 g), copper (I) chloride (0.42 g), molecular sieve 4A (2.8 g) tetrahydrofuran (50 ml), 1-(4-difluoromethoxyphenyl)-1-formylcyclopropane, acetic anhydride (1.5 ml) and methyl dichlorofluoroacetate (3.6 g) to yield the title compound (0.79 g, 28%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763700 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-7182948a159947419d437f1f4683d20d |
| Source note | uspto-grants-1998_06 |