HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → 1-(2-Fluoro-3-hydroxyprop-1-enyl)-1-(2-fluoro-4-trifluoromethylphenyl)cyclopropane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 1-(2-Fluoro-2-(methoxycarbonyl)ethenyl)-1-(2-fluoro-4-trifluoromethylphenyl) cyclopropane | HCID 54160134 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(2-Fluoro-3-hydroxyprop-1-enyl)-1-(2-fluoro-4-trifluoromethylphenyl)cyclopropane | HCID 54113895 | 77.2% |
Reaction Steps
The method of Example 9 was repeated using 1-(2-Fluoro-2-(methoxycarbonyl)ethenyl)-1-(2-fluoro-4-trifluoromethylphenyl)-cyclopropane (Example 5) (0.77 g), diethyl ether (10 ml) and lithium aluminium hydride (0.18 g) to yield the title compound (0.54 g, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763700 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-05b87e44c9e1408fbf20e1f2baa2fd75 |
| Source note | uspto-grants-1998_06 |