反应详情

Acetyl chloride (0.72 ml) was slowly added to a stirred solution of 1-(4-chlorophenyl)-1-(2-fluoro-3-hydroxyprop-1-enyl)cyclopropane (Example 9) (0.36 g) in benzene (20 ml) and pyridine (0.14 ml) at 0° C., and stirring was continued for 24 h while the mixture warmed to room temperature. After addition of water (10 ml), the mixture was extracted with diethyl ether (3×20 ml) and the combined organic layers were washed with water (3×10 ml) and evaporated under reduced pressure. The residue was chromatographed on silica using diethyl ether/hexane (1:9) to yield 1-(3-acetoxy-2-fluoroprop-1-enyl)-1-(4-chlorophenyl)cyclopropane (0.37 g, 87%).

1. extractionthe mixture was extracted with diethyl ether (3×20 ml)
2. washthe combined organic layers were washed with water (3×10 ml)
3. customevaporated under reduced pressure
4. customThe residue was chromatographed on silica