Benzene → 1-(3-Acetoxy-2-fluoroprop-1-enyl)-1-(4-trifluoromethoxyphenyl)cyclopropane

HRID 963819Notes

Reaction equation

HRID 963819 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[F:5][C:6]([CH2:22][OH:23])=[CH:7][C:8]1([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)[CH2:10][CH2:9]1.C1C=CC=CC=1>N1C=CC=CC=1>[C:1]([O:23][CH2:22][C:6]([F:5])=[CH:7][C:8]1([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:19])([F:21])[F:20])=[CH:13][CH:12]=2)[CH2:9][CH2:10]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 241BenzeneHCID 6367Acetyl chlorideHCID 542310441-(2-Fluoro-3-hydroxyprop-1-enyl)-1-(4-trifluoromethoxyphenyl)cyclopropane

Product 1

HCID 542419931-(3-Acetoxy-2-fluoroprop-1-enyl)-1-(4-trifluoromethoxyphenyl)cyclopropaneYield 92%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The method of Example 17 was repeated using acetyl chloride (0.46 ml), 1-(2-fluoro-3-hydroxyprop-1-enyl)-1-(4-trifluoromethoxy-phenyl)cyclopropane (Example 11) (0.25 g), benzene (12 ml) and pyridine (0.09 ml) to yield the title compound (0.27 g, 92%).

Sources & evidence

ORD record
ord-542bbc215b7542fc96868af3f317d841
Source dataset
uspto-grants-1998_06
Patent number
US05763700

Reaction notes

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