Benzene → 1-(3-Acetoxy-2-fluoroprop-1-enyl)-1-(4-fluorophenyl)cyclopropane

HRID 963820Notes

Reaction equation

HRID 963820 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[F:5][C:6]([CH2:18][OH:19])=[CH:7][C:8]1([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH2:10][CH2:9]1.C1C=CC=CC=1>N1C=CC=CC=1>[C:1]([O:19][CH2:18][C:6]([F:5])=[CH:7][C:8]1([C:11]2[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=2)[CH2:10][CH2:9]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 241BenzeneHCID 6367Acetyl chlorideHCID 537794621-(2-Fluoro-3-hydroxyprop-1-enyl)-1-(4-fluorophenyl)cyclopropane

Product 1

HCID 536458661-(3-Acetoxy-2-fluoroprop-1-enyl)-1-(4-fluorophenyl)cyclopropaneYield 96%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The method of Example 17 was repeated using acetyl chloride (0.46 ml), 1-(2-fluoro-3-hydroxyprop-1-enyl)-1-(4-fluorophenyl)cyclopropane (Example 12) (0.2 g), benzene (12 ml) and pyridine to yield the title compound (0.23 g, 96%).

Sources & evidence

ORD record
ord-f922490b341b432badd47ae777cb601b
Source dataset
uspto-grants-1998_06
Patent number
US05763700

Reaction notes

Loading…