Benzene → 1-(3-Acetoxy-2-fluoroprop-1-enyl)-1-(4-difluoromethoxyphenyl)cyclopropane

HRID 963824Notes

Reaction equation

HRID 963824 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[F:5][CH:6]([F:22])[O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2([CH:17]=[C:18]([F:21])[CH2:19][OH:20])[CH2:16][CH2:15]2)=[CH:10][CH:9]=1.C1C=CC=CC=1>N1C=CC=CC=1>[C:1]([O:20][CH2:19][C:18]([F:21])=[CH:17][C:14]1([C:11]2[CH:10]=[CH:9][C:8]([O:7][CH:6]([F:5])[F:22])=[CH:13][CH:12]=2)[CH2:16][CH2:15]1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 241BenzeneHCID 6367Acetyl chlorideHCID 541079581-(4-Difluoromethoxyphenyl)-1-(2-fluoro-3-hydroxyprop-1-enyl)cyclopropane

Product 1

HCID 544373871-(3-Acetoxy-2-fluoroprop-1-enyl)-1-(4-difluoromethoxyphenyl)cyclopropaneYield 99%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The method of Example 17 was repeated using acetyl chloride (0.92 ml), 1-(4-difluoromethoxyphenyl)-1-(2-fluoro-3-hydroxyprop-1-enyl)cyclopropane Example 16) (0.49 g), benzene (24 ml) and pyridine (0.2 ml) to yield the title compound (0.55 g, 99%).

Sources & evidence

ORD record
ord-bedacf9e13e24bbeb4867ada46259eaa
Source dataset
uspto-grants-1998_06
Patent number
US05763700

Reaction notes

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