HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyloxycarbonylglycine → HCID 47117222, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyloxycarbonylglycine | HCID 14349 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 47117222 | HCID 47117222 | 80.7% |
Reaction Steps
23.1 g of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) are added while stirring to 24 g of N-benzyloxycarbonyl-glycine and 8 ml of cyclopropylamine in 240 ml of methylene chloride and the mixture stirred at room temperature for 4 hours. The mixture is taken up in ether and washed with 1N hydrochloric acid, with bicarbonate solution and with water. After drying and evaporating the ether phase there are obtained 23 g of benzyloxycarbonylamino-acetic acid cyclopropylamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763604 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-b58a3cb550b04d7bb3edbadf21ff622d |
| Source note | uspto-grants-1998_06 |