HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Tert-butyl 1-(aminoimino-methyl)-piperidin-4-ylmethylcarbamate hemisulfite
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Tert-butyl (piperidin-4-ylmethyl)carbamate | HCID 723429 | — |
| Reactant | Methanesulfonic acid, aminoimino- | HCID 9877361 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Tert-butyl 1-(aminoimino-methyl)-piperidin-4-ylmethylcarbamate hemisulfite | HCID 131720709 | — |
Reaction Steps
A solution of 130 g of 1,1-dimethylethyl (4piperidinylmethyl)-carbamate in 1300 ml of DMF is treated with 138 ml of triethylamine and 61.8 g of formamidinesulfonic acid and the mixture is stirred at room temperature overnight. The precipitated material is filtered, suspended in 500 ml of ethanol, again filtered off and dried. There are obtained 65.6 g of tert-butyl 1-(aminoimino-methyl)-piperidin-4-ylmethylcarbamate hemisulfite, MS (ISP): 257.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05763604 |
| Source dataset | uspto-grants-1998_06 |
| ORD ID | ord-86e6069001dc41e4af4476953984ac18 |
| Source note | uspto-grants-1998_06 |